As the fiercely dedicated general practitioner who tries to help the sick, the poor and the unfortunate in his decrepit neighborhood, Paul Muni is the testy old man who faces life without compromise and David Wayne is the troubled television executive fighting to preserve his career.

Two New York City longshoremen Axel Nordmann, an Army deserter and Tommy Tyler, an easy-going freight car loader whose growing friendship is threatened by Charles Malik, a notably repellent punk.

Schoolteacher and family man Ed Avery, who's been suffering bouts of severe pain and even blackouts, is hospitalized with what's diagnosed as a rare inflammation of the arteries. Told by doctors that he probably has only months to live, Ed agrees to an experimental treatment: doses of the hormone cortisone. Ed makes a remarkable recovery, and returns home to his wife, Lou, and their son, Richie. He must keep taking cortisone tablets regularly to prevent a recurrence of his illness. But the "miracle" cure turns into its own nightmare as Ed starts to abuse the tablets, causing him to experience increasingly wild mood swings.

A submarine newly commissioned is damaged in the opening days of WW II. A captain, looking for a command insists he can get it to a dockyard and captain it. Going slowly to this site, they find a stranded group of Army nurses and must take them aboard. How bad can it get? Trying to get a primer coat on the sub, they have to mix white and red in order to have enough. When forced to flee the dock during an air attack, they find themselves with the world's only Pink submarine, still with 5 women in the tight quarters of a submarine.